All Researchers

CityU

Brain-Machine Interface, Spiking Neural Networks

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HKU

Motivation, Neuromodulation, Neuroimaging

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CUHK

Animal Disease Models of Neurodegeneration, Drug Discovery, Repeat Expansion Diseases, RNA Toxicity

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Professor Edwin Chan Ho-yin is Director and Professor in the School of Life Sciences,
CUHK. He received undergraduate training in biochemistry from CUHK, doctoral training at The University of Cambridge (UK) and postdoctoral training at The University of Pennsylvania (US). Since 1999, Professor Chan has been investigating rare neurological and neuromuscular disorders. In 2014, he established an intercontinental research collaboration network on rare neuronal diseases, including Huntington’s disease, amyotrophic lateral sclerosis, myotonic dystrophy and spinocerebellar ataxia.

HKUST

Alzheimer’s Disease, Brain Lipid Metabolism, TREM2, APOE

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HKU-SZH

Neurological Diseases, Stroke, Neurointervention

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HKU

Developmental Dyslexia, ASD, fMRI

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My research concerns brain changes in developmental disorders such as developmental dyslexia, ASD and ADHD. Specifically, we are interested in brain structural and functional changes with behavioral interventions and brain stimulations. I use multiple neuroimaging techniques in my research such as EEG, fNIRS, fMRI and tACS.

HKU

Neuroimmonology

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K H Chan’s research interests include autoimmune neurological disorders (multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, myasthenia gravis) and neuroinflammation of Alzheimer disease (AD). He is actively researching to develop novel immunotherapies for MS and NMO, understand AD pathophysiologies and develop personalized therapeutics for AD and other neurodegenerative diseases causing cognitive impairment.

CityU

Neural Device Interface, Retinal Electrical Stimulation

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HKU

Flexible Electronics, Sensors, Transistors

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My research focuses on flexible electronics for brain-computer interface (BCI) applications. This includes the development of conformal ECoG sensors, high-density neural probes, chemical transistor-based sensors, and integrated signal processing circuits. Our work spans from device fabrication and data acquisition to signal processing and AI algorithm development. We welcome opportunities to collaborate with researchers and partners in the BCI field.

CityU

Neural Prosthesis, Brain-Computer Interface

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HKU

Neuromuscular Diseases, Stem Cells

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HKU

Neural Plasticity, Circuitry Development, Injury Rewiring

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HKU

Visual perception, Binocular Vision, Plasticity, MRI, TMS

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Prof Chang's research seeks to unravel the neural mechanisms underlying visual perception, with a particular emphasis on binocular vision (stereoscopic depth perception, sensory eye dominance) and its corresponding neuroplastic capacity. Her work uses a combination of psychophysics (perceptual learning), neuroimaging (fMRI, DTI, MRS, E/MEG), and brain stimulation (TMS) techniques.

HKU

Neurodegeneration, Alzheimer's disease, Parkinson's Disease Dementia, Neuroinflammation, Microglia, Microbiota, PKR

Research Description

To prevent cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease dementia, we should investigate the cellular and molecular mechanisms of different risk factors. Having collaborated with our colleagues in the LKS Faculty of Medicine, we have investigated how cigarette smoking, environmental pollution, wound injury, infection, surgery, stress/depression, obesity, and organ failure affect the brain. We find one communal pathway is the systemic immune responses, which can immediately trigger neuroinflammation. Consequently, neuroinflammation stimulates deposit pathological proteins in the brain and further triggers infiltration of systemic macrophages and resident microglia. Our laboratory is now investigate how infiltration of systemic macrophages occurs and how we can modulate neuroinflammation in order to attenuate progression of neurodegeneration.

HKU

Psychosis, Bipolar Disorder

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CityU

Higher Order Cortex, Primary Sensory Cortex, Neural Circuit, Innate Responses, Associative Memory

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Prof. Chen’s research interests are studying how the higher-order cortical areas encode information with high valence and how these areas modulate activities in sensory or other lower-level regions, by anatomical examination, physiological recordings, optogenetic/chemogenetic manipulations, and behavioural tests.

HKU

Neurooncology

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HKU

Neural Crest Formation, Neurological Disease Modelling

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Embryonic development involves complex genetic regulation of cell growth, migration, and differentiation. Our research uses diverse experimental approaches to study these processes, focusing on neural crest development in melanoma and motor neuron degeneration in spinal muscular atrophy, aiming to develop therapeutic strategies for both congenital diseases and cancer treatment approaches.

HKU

Visual Psychophysics, Cortical Plasticity

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CUHK

Machine Learning, Motor Control, Stroke Rehabilitation

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HKU

Clinical Psychopharmacology, Substance Misuse

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HKU-SZH

Epilepsy, Hemifacial Spasm, Focal Dystonia, Stroke, Neuroimmune Disease

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CUHK

Optogenetics, Photoactivable Proteins

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CityU

Neural Mathematical Modelling

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HKUST

Generative AI, Language Learning, Vision-Language Modelling

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HKU

Cephalopod, All-Optical Experimentation, Visual Processing  

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CityU

Neocortex Memory Encoding, Hearing

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Prof He’s lab combines electrophysiological, anatomical, and engineering approaches to understand hearing, learning, memory, and attention. Prof. He is involved in drug development for brain disorders like Alzheimer’s disease, epilepsy, tinnitus, amblyopia, and depression. The drug development projects are carried out in collaboration with the Hong Kong Institute of Science and Innovation, Chinese Academy of Sciences.

HKU

Respiratory Cell Regeneration and Interaction, Disease Modelling

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HKUST

Behavioural Plasticity, Diversity, Proteomics

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HKU

Social Learning and Sleep

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HKUST

Neural Population Activity, Biological Motion, Statistical Theory

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HKBU

Biochemistry, Developmental Neuroscience, Neurological Disorders

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CityU

Synaptic Transmission, E/I Balance

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HKU

Intracellular Transportation, Microtubule, Actin, Kinesin

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Our major research interest is in the mechanism of intracellular transportation and its roles in development, neuronal function and genetic diseases. Intracellular transportation is carried out over two major cellular networks, the microtubule and actin networks.

Our studies demonstrated that myosin-VA can interact directly with the ubiquitously expressed kinesin, implying that the two transportation systems are at least partially coordinated through their motor molecules. The major interest of our group is to use transgenic and knockout mice to study the functions of kinesins in chondrocytes, neurons, and other cell types.

CUHK

Neurodevelopmental Disorders, Hippocampal Dependent Learning, Circular RNA, RNA granules, Two-Photon Imaging

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Our group at CUHK is interested in: 1) The mechanisms and potential therapeutics of neurodevelopmental disorders. 2) Molecular and circuit mechanisms of learning and memory. We employ a range of techniques, including molecular and systems neuroscience tools.

HKUST

Neural Development, Neurotrophic Factors, Neurological Drugs

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Prof Ip’s lab focusses on understanding neural development and function, as well as drug discovery for neurodegenerative diseases such as Alzheimer’s disease. Prof Ip has made seminal discoveries in the biology of neurotrophic factors, which are proteins that promote the survival, development, and maintenance of neurons in the nervous system. Her group has also made important contributions towards understanding the molecular mechanisms underlying brain development and synaptic plasticity, and their dysregulation in neurological disorders.

HKU

Neural Stem Cells, Cellular Reprogramming

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HKU

Anxiety and Depression

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CUHK

Emotions, Social Behavior, Higher Cognitive Functions

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CityU

Circadian Clocks, Neurodegeneration

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HKU

Tumor-Brain Interaction, Systemic Inflammation, Blood-Brain Barrier Permeability, Neuronal Damage, Drosophila Tumor Model

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Tumor-induced systemic inflammation disrupting the blood-brain barrier and neurons in Drosophila tumor models

HKBU

Cognition, Emotions

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PolyU

Non-invasive Brain Stimulation, Neuroimaging, Neurotransmitters

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CUHK

Neurodegenerative Disorders, Sensorimotor Circuits, Neurotechnology

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HKU

Dendritic Spine Plasticity, Fear, Sleep, Learning and Memory

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Our lab uses in vivo imaging, optogentics, chemogenetics, genetic manipulations, and behavioural approaches to understand synaptic plasticity, neural circuits, and the role of sleep in emotional learning, which will provide insight to help us to better understand the aetiology and therapeutic interventions for psychiatric disorders such as depression, schizophrenia.

CityU

Synapse, RNA transport, Cytoskeleton, hiPSC-neurons

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Understanding the molecular basis of how neuronal synapses in the brain change during development and in response to synaptic activity, focusing on the synaptic transport of RNAs. Also employ human iPSC-derived neurons to study disease-related mutations on synaptic function

HKU

Emotional Memories, Fear and Anxiety, Neurocognitive Assessment, Mental Health, Clinical Psychology

Research Description

The Laboratory of Clinical Psychology and Affective Neuroscience focuses on identifying mechanisms contributing to pathological fear and anxiety, with the goal of developing targeted interventions for affect and mood dysregulation and enhancing psychological well-being. We use a combination of physiological measures (e.g. pupillometry), functional neuroimaging (fMRI), and behavioural experiments to answer the research questions.

HKU

Stroke and Recovery

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CityU

Cortical Plasticity

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HKU

Neural Surgery, Epilepsy

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HKBU

ECM, Synaptic Development, Neurotrophic Signalling

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HKU

Clinical Psychology, Human Neuroimaging

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Prof Lee’s research is at the frontiers of neuropsychology and human neuroscience. Her team is dedicated to unravelling the neuroplastic mechanisms underpinning adaptive and maladaptive cognitive and affective functioning across the life span. Her current research focuses on factors protecting brain and psychological health.

CityU

Glial Biology, Neurodevelopment

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HKU

Glaucoma, Optic Neuropathies

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HKU

Neurosurgery

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CityU

Language, fMRI, MEG, EEG, Computational Modeling

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Jixing Li is an Assistant Professor in the Department of Linguistics and Translation at City University of Hong Kong. She earned her PhD in Linguistics from Cornell University in 2019 and completed her postdoctoral training at NYU Abu Dhabi’s Neuroscience of Language Lab. Her interdisciplinary research leverages computational modeling to investigate how the human brain comprehends language, bridging linguistics, psychology, cognitive neuroscience, and natural language processing. Her work has been published in Nature Computational Science, eLife, Journal of Neuroscience, Imaging Neuroscience, Scientific Data etc. and top NLP conferences ACL, NAACL, and EMNLP.

HKU

Sleep Disorders, Psychopathology, Cognition, Affective Disorders, Psychosis, Youth Mental Health

Research Description

Shirley Li is an associate professor from Department of Psychology, The University of Hong Kong. She is a registered clinical psychologist in the UK and HK. Dr. Li’s clinical and research interests centre on sleep and sleep disorders, particularly sleep disturbance and mental health, and psychological and behavioural treatments of sleep problems in the context of psychiatric and medical illnesses across the lifespan. As a clinician-researcher, she is experienced in conducting laboratory, clinical and epidemiologic studies as well as translational research, which are interdisciplinary across clinical psychology, psychiatry, and sleep medicine.

CityU

Pain, Anterior Cingulate Cortex, Hippocampal-Cortical Network

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CityU

Neuronal-Glial Fate Determination and Interaction

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HKUST

Axon Regeneration, CNS Injury Recovery

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CityU

C. elegans Neuron Reconstruction

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Our research investigates how gut microbiota interact with neural circuits to influence chronic pain and its comorbidities, explores glial modulation of pain pathways, and advances the development of novel analgesics.

HKU

Neuroprotection in Ischemia

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HKU

NeuroAI, Visual Perception, Generative Models

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CityU

Axon Regeneration

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HKU

Memory Persistence, Autism Spectrum Disorder, Neuron-specific Microexon, Amyloid, CPEB, Cryogenic Electron Microscopy

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My research investigates how aggregation of CPEB proteins underlies memory persistence and contributes to autism spectrum disorder. Using cryo-EM, biochemistry, and animal models, we aim to understand both functional and pathological CPEB aggregation, providing insight into long-term memory mechanisms and informing new treatments for Alzheimer’s, ASD, and related neurological diseases.

HKU

Social Behaviour

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PolyU

Therapy and Rehabilitation for Stroke and Dementia Patients

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HKUST

Live Biological Imaging, Nonlinear Microscopy

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CUHK

Auditory Perception, Cochlear Implant, Sensory Plasticity

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The Schnupp Lab focuses on how sensory processing interprets auditory inputs to the brain and how they are transformed to underpin subjective perceptual qualities of sound such as pitch, timbre and sound source location. They are also studying how the brain learns to adapt to the statistical structure of the sounds in our environment to form efficient neural representations of sound and to support auditory scene analysis. This work has important implications for design and use of auditory prosthetics.

HKU

Neurogenomics, Adaptation, Environmental Effect on Behaviour

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HKUST

Visual Behavior in Zebrafish ㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤ

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HKU

Genome Wide Association Studies, Psychiatric Disorders, Epidemiology

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HKU

Alzheimer’s Disease

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CityU

Epitranscriptomics, Neurodegenerative Diseases

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HKU

Stroke, Intracerebral Hemorrhage

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CUHK

Auditory, Music, Speech, Neuroscience, Oscillation

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Xiangbin TENG is an assistant professor in the Department of Psychology at the Chinese University of Hong Kong. He received his Ph.D. in Cognition and Perception from New York University and previously conducted research at the Max Planck Institutes in Frankfurt am Main and Berlin, Germany. His research focuses on how the brain dynamically encodes and predicts temporal structure in naturalistic auditory signals, such as speech and music.

HKBU

Complex Multimodal Brain Data, Computational Neuroscience

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CityU

Brain-Computer Interface, Machine Learning, Neural Computation

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HKU

Optical Microscopy and Spectroscopy, Single-Cell Analysis

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HKU

Neurodisabilities in Children

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HKU

Nanomaterial, Neuromorphic Computing, Optoelectronics

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CityU

Photoacoustic Imaging, Biophotonics

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HKU

Microglia, Alzheimer’s Disease

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HKU

Effect of Anaesthesia on Neuronal Function and Cognition

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CUHK

Synaptic Plasticity, Axonal Biology, Local Protein Synthesis, mRNA, Multipatch, 2-Photon Microscopy/Manipulation

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The H.Wong Lab focuses on brain circuit formation, maintenance, and plasticity, with a strong emphasis on understanding the molecular signalling at brain connections, known as synapses. By uncovering fundamental principles of information processing and memory storage, this knowledge is leveraged to reveal synaptic targets for alleviating neurological disorders.

HKU

Ultrafast Optical Fiber Communication and Imaging

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CUHK

Language Learning, Speech Perception, Communicative Disorders

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CityU

Language Processing

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HKU

Neuroimaging, MRI Development

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HKU-SZH

Epilepsy, Neuroimmune Disease, Parkinson’s Disease

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CityU

Brain Mapping, Map Plasticity, Psychiatry Disorders, Neural Implant, Neuro-nanomaterials

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We study the mechanistic understanding of sensorimotor processing and the cellular mechanisms of learning and memory using modern techniques such as in vivo multichannel recording, two-photon imaging, in vivo whole-cell recording, and various behavioral tasks. This research will ultimately be applied to alleviate various brain diseases.

CityU

Flexible Electronics, Bio-integrated Electronics

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EduU

Neural Stem Cell, Neurodegenerative Diseases

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HKU-SZH

Rare Neurological Disorders, Motor Neuron Disease, Peripheral Neuromuscular Disease, Neurospinal Disorder

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CityU

Optical Microscopy, Fluorescence Imaging, In vivo Mouse Brain & Eye Imaging, Adaptive Optics, Multi-photon, SIM

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My primary research focuses on developing cutting-edge microscopy technologies for biological studies, particularly for in vivo imaging of the mouse brain and eye.

CityU

Decision Making, Learning, Social Reasoning

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Decision making and learning with fMRI and EEG.

HKU

Cell Biology of Neurogenesis

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CityU

Genomics, Networks Mapping, Neurodevelopment

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