Neurodegenerative Disease

University of Hong Kong

Dementia, Alzheimer’s Disease

University of Hong Kong

Memory Persistence, Autism Spectrum Disorder, Neuron-specific Microexon, Amyloid, CPEB, Cryogenic Electron Microscopy

My research investigates how aggregation of CPEB proteins underlies memory persistence and contributes to autism spectrum disorder. Using cryo-EM, biochemistry, and animal models, we aim to understand both functional and pathological CPEB aggregation, providing insight into long-term memory mechanisms and informing new treatments for Alzheimer’s, ASD, and related neurological diseases.

Chinese University of Hong Kong

RNA and Protein Toxicity in Neurological Diseases, Disease Modelling

Hong Kong Polytechnic University

Therapy and Rehabilitation for Stroke and Dementia Patients

University of Hong Kong

Alzheimer’s Disease

Hong Kong University of Science and Technology

Neural Development, Neurotrophic Factors, Neurological Drugs

Prof Ip’s lab focusses on understanding neural development and function, as well as drug discovery for neurodegenerative diseases such as Alzheimer’s disease. Prof Ip has made seminal discoveries in the biology of neurotrophic factors, which are proteins that promote the survival, development, and maintenance of neurons in the nervous system. Her group has also made important contributions towards understanding the molecular mechanisms underlying brain development and synaptic plasticity, and their dysregulation in neurological disorders.