Neurodegenerative Disease

HKUST

Alzheimer’s Disease, Brain Lipid Metabolism, TREM2, APOE

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CUHK

Animal Disease Models of Neurodegeneration, Drug Discovery, Repeat Expansion Diseases, RNA Toxicity

Research Description

Professor Edwin Chan Ho-yin is Director and Professor in the School of Life Sciences,
CUHK. He received undergraduate training in biochemistry from CUHK, doctoral training at The University of Cambridge (UK) and postdoctoral training at The University of Pennsylvania (US). Since 1999, Professor Chan has been investigating rare neurological and neuromuscular disorders. In 2014, he established an intercontinental research collaboration network on rare neuronal diseases, including Huntington’s disease, amyotrophic lateral sclerosis, myotonic dystrophy and spinocerebellar ataxia.

HKU

Neurodegeneration, Alzheimer's disease, Parkinson's Disease Dementia, Neuroinflammation, Microglia, Microbiota, PKR

Research Description

To prevent cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease dementia, we should investigate the cellular and molecular mechanisms of different risk factors. Having collaborated with our colleagues in the LKS Faculty of Medicine, we have investigated how cigarette smoking, environmental pollution, wound injury, infection, surgery, stress/depression, obesity, and organ failure affect the brain. We find one communal pathway is the systemic immune responses, which can immediately trigger neuroinflammation. Consequently, neuroinflammation stimulates deposit pathological proteins in the brain and further triggers infiltration of systemic macrophages and resident microglia. Our laboratory is now investigate how infiltration of systemic macrophages occurs and how we can modulate neuroinflammation in order to attenuate progression of neurodegeneration.

HKUST

Neural Development, Neurotrophic Factors, Neurological Drugs

Research Description

Prof Ip’s lab focusses on understanding neural development and function, as well as drug discovery for neurodegenerative diseases such as Alzheimer’s disease. Prof Ip has made seminal discoveries in the biology of neurotrophic factors, which are proteins that promote the survival, development, and maintenance of neurons in the nervous system. Her group has also made important contributions towards understanding the molecular mechanisms underlying brain development and synaptic plasticity, and their dysregulation in neurological disorders.

HKU

Memory Persistence, Autism Spectrum Disorder, Neuron-specific Microexon, Amyloid, CPEB, Cryogenic Electron Microscopy

Research Description

My research investigates how aggregation of CPEB proteins underlies memory persistence and contributes to autism spectrum disorder. Using cryo-EM, biochemistry, and animal models, we aim to understand both functional and pathological CPEB aggregation, providing insight into long-term memory mechanisms and informing new treatments for Alzheimer’s, ASD, and related neurological diseases.

PolyU

Therapy and Rehabilitation for Stroke and Dementia Patients

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HKU

Alzheimer’s Disease

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CityU

Epitranscriptomics, Neurodegenerative Diseases

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HKU

Microglia, Alzheimer’s Disease

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