University of Hong Kong

HKU

Motivation, Neuromodulation, Neuroimaging

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HKU-SZH

Neurological Diseases, Stroke, Neurointervention

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HKU

Developmental Dyslexia, ASD, fMRI

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My research concerns brain changes in developmental disorders such as developmental dyslexia, ASD and ADHD. Specifically, we are interested in brain structural and functional changes with behavioral interventions and brain stimulations. I use multiple neuroimaging techniques in my research such as EEG, fNIRS, fMRI and tACS.

HKU

Neuroimmonology

Research Description

K H Chan’s research interests include autoimmune neurological disorders (multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, myasthenia gravis) and neuroinflammation of Alzheimer disease (AD). He is actively researching to develop novel immunotherapies for MS and NMO, understand AD pathophysiologies and develop personalized therapeutics for AD and other neurodegenerative diseases causing cognitive impairment.

HKU

Flexible Electronics, Sensors, Transistors

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My research focuses on flexible electronics for brain-computer interface (BCI) applications. This includes the development of conformal ECoG sensors, high-density neural probes, chemical transistor-based sensors, and integrated signal processing circuits. Our work spans from device fabrication and data acquisition to signal processing and AI algorithm development. We welcome opportunities to collaborate with researchers and partners in the BCI field.

HKU

Neuromuscular Diseases, Stem Cells

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HKU

Neural Plasticity, Circuitry Development, Injury Rewiring

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HKU

Visual perception, Binocular Vision, Plasticity, MRI, TMS

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Prof Chang's research seeks to unravel the neural mechanisms underlying visual perception, with a particular emphasis on binocular vision (stereoscopic depth perception, sensory eye dominance) and its corresponding neuroplastic capacity. Her work uses a combination of psychophysics (perceptual learning), neuroimaging (fMRI, DTI, MRS, E/MEG), and brain stimulation (TMS) techniques.

HKU

Neurodegeneration, Alzheimer's disease, Parkinson's Disease Dementia, Neuroinflammation, Microglia, Microbiota, PKR

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To prevent cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease dementia, we should investigate the cellular and molecular mechanisms of different risk factors. Having collaborated with our colleagues in the LKS Faculty of Medicine, we have investigated how cigarette smoking, environmental pollution, wound injury, infection, surgery, stress/depression, obesity, and organ failure affect the brain. We find one communal pathway is the systemic immune responses, which can immediately trigger neuroinflammation. Consequently, neuroinflammation stimulates deposit pathological proteins in the brain and further triggers infiltration of systemic macrophages and resident microglia. Our laboratory is now investigate how infiltration of systemic macrophages occurs and how we can modulate neuroinflammation in order to attenuate progression of neurodegeneration.

HKU

Psychosis, Bipolar Disorder

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HKU

Neural Crest Formation, Neurological Disease Modelling

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Embryonic development involves complex genetic regulation of cell growth, migration, and differentiation. Our research uses diverse experimental approaches to study these processes, focusing on neural crest development in melanoma and motor neuron degeneration in spinal muscular atrophy, aiming to develop therapeutic strategies for both congenital diseases and cancer treatment approaches.

HKU

Visual Psychophysics, Cortical Plasticity

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HKU

Clinical Psychopharmacology, Substance Misuse

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HKU-SZH

Epilepsy, Hemifacial Spasm, Focal Dystonia, Stroke, Neuroimmune Disease

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HKU

Cephalopod, All-Optical Experimentation, Visual Processing

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HKU

Respiratory Cell Regeneration and Interaction, Disease Modelling

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HKU

Memory Persistence, Autism Spectrum Disorder, Neuron-specific Microexon, Amyloid, CPEB, Cryogenic Electron Microscopy

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My research investigates how aggregation of CPEB proteins underlies memory persistence and contributes to autism spectrum disorder. Using cryo-EM, biochemistry, and animal models, we aim to understand both functional and pathological CPEB aggregation, providing insight into long-term memory mechanisms and informing new treatments for Alzheimer’s, ASD, and related neurological diseases.

HKU

Social Learning and Sleep

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HKU

Intracellular Transportation, Microtubule, Actin, Kinesin

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Our major research interest is in the mechanism of intracellular transportation and its roles in development, neuronal function and genetic diseases. Intracellular transportation is carried out over two major cellular networks, the microtubule and actin networks.

Our studies demonstrated that myosin-VA can interact directly with the ubiquitously expressed kinesin, implying that the two transportation systems are at least partially coordinated through their motor molecules. The major interest of our group is to use transgenic and knockout mice to study the functions of kinesins in chondrocytes, neurons, and other cell types.

HKU

Neural Stem Cells, Cellular Reprogramming

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HKU

Anxiety and Depression

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HKU

Tumor-Brain Interaction, Systemic Inflammation, Blood-Brain Barrier Permeability, Neuronal Damage, Drosophila Tumor Model

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Tumor-induced systemic inflammation disrupting the blood-brain barrier and neurons in Drosophila tumor models

HKU

Dendritic Spine Plasticity, Fear, Sleep, Learning and Memory

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Our lab uses in vivo imaging, optogentics, chemogenetics, genetic manipulations, and behavioural approaches to understand synaptic plasticity, neural circuits, and the role of sleep in emotional learning, which will provide insight to help us to better understand the aetiology and therapeutic interventions for psychiatric disorders such as depression, schizophrenia.

HKU

Emotional Memories, Fear and Anxiety, Neurocognitive Assessment, Mental Health, Clinical Psychology

Research Description

The Laboratory of Clinical Psychology and Affective Neuroscience focuses on identifying mechanisms contributing to pathological fear and anxiety, with the goal of developing targeted interventions for affect and mood dysregulation and enhancing psychological well-being. We use a combination of physiological measures (e.g. pupillometry), functional neuroimaging (fMRI), and behavioural experiments to answer the research questions.

HKU

Stroke and Recovery

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HKU

Clinical Psychology, Human Neuroimaging

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Prof Lee’s research is at the frontiers of neuropsychology and human neuroscience. Her team is dedicated to unravelling the neuroplastic mechanisms underpinning adaptive and maladaptive cognitive and affective functioning across the life span. Her current research focuses on factors protecting brain and psychological health.

HKU

Glaucoma, Optic Neuropathies

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HKU

Neurosurgery

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HKU

Sleep Disorders, Psychopathology, Cognition, Affective Disorders, Psychosis, Youth Mental Health

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Shirley Li is an associate professor from Department of Psychology, The University of Hong Kong. She is a registered clinical psychologist in the UK and HK. Dr. Li’s clinical and research interests centre on sleep and sleep disorders, particularly sleep disturbance and mental health, and psychological and behavioural treatments of sleep problems in the context of psychiatric and medical illnesses across the lifespan. As a clinician-researcher, she is experienced in conducting laboratory, clinical and epidemiologic studies as well as translational research, which are interdisciplinary across clinical psychology, psychiatry, and sleep medicine.

HKU

Neuroprotection in Ischemia

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HKU

NeuroAI, Visual Perception, Generative Models

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HKU

Social Behaviour

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HKU

Neurogenomics, Adaptation, Environmental Effect on Behaviour

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HKU

Alzheimer’s Disease

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HKU

Stroke, Intracerebral Hemorrhage

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HKU

Optical Microscopy and Spectroscopy, Single-Cell Analysis

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HKU

Neurodisabilities in Children

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HKU

Nanomaterial, Neuromorphic Computing, Optoelectronics

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HKU

Microglia, Alzheimer’s Disease

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HKU

Effect of Anaesthesia on Neuronal Function and Cognition

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HKU

Ultrafast Optical Fiber Communication and Imaging

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HKU

Neuroimaging, MRI Development

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HKU-SZH

Epilepsy, Neuroimmune Disease, Parkinson’s Disease

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HKU-SZH

Rare Neurological Disorders, Motor Neuron Disease, Peripheral Neuromuscular Disease, Neurospinal Disorder

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HKU

Cell Biology of Neurogenesis

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