Cellular and Molecular Neuroscience

HKU

Neural Plasticity, Circuitry Development, Injury Rewiring

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HKU

Neural Crest Formation, Neurological Disease Modelling

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Embryonic development involves complex genetic regulation of cell growth, migration, and differentiation. Our research uses diverse experimental approaches to study these processes, focusing on neural crest development in melanoma and motor neuron degeneration in spinal muscular atrophy, aiming to develop therapeutic strategies for both congenital diseases and cancer treatment approaches.

CUHK

Optogenetics, Photoactivable Proteins

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HKU

Respiratory Cell Regeneration and Interaction, Disease Modelling

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HKUST

Behavioural Plasticity, Diversity, Proteomics

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HKBU

Biochemistry, Developmental Neuroscience, Neurological Disorders

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CityU

Synaptic Transmission, E/I Balance

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HKU

Intracellular Transportation, Microtubule, Actin, Kinesin

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Our major research interest is in the mechanism of intracellular transportation and its roles in development, neuronal function and genetic diseases. Intracellular transportation is carried out over two major cellular networks, the microtubule and actin networks.

Our studies demonstrated that myosin-VA can interact directly with the ubiquitously expressed kinesin, implying that the two transportation systems are at least partially coordinated through their motor molecules. The major interest of our group is to use transgenic and knockout mice to study the functions of kinesins in chondrocytes, neurons, and other cell types.

CUHK

Neurodevelopmental Disorders, Hippocampal Dependent Learning, Circular RNA, RNA granules, Two-Photon Imaging

Research Description

Our group at CUHK is interested in: 1) The mechanisms and potential therapeutics of neurodevelopmental disorders. 2) Molecular and circuit mechanisms of learning and memory. We employ a range of techniques, including molecular and systems neuroscience tools.

HKU

Neural Stem Cells, Cellular Reprogramming

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HKU

Tumor-Brain Interaction, Systemic Inflammation, Blood-Brain Barrier Permeability, Neuronal Damage, Drosophila Tumor Model

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Tumor-induced systemic inflammation disrupting the blood-brain barrier and neurons in Drosophila tumor models

CityU

Synapse, RNA transport, Cytoskeleton, hiPSC-neurons

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Understanding the molecular basis of how neuronal synapses in the brain change during development and in response to synaptic activity, focusing on the synaptic transport of RNAs. Also employ human iPSC-derived neurons to study disease-related mutations on synaptic function

HKBU

ECM, Synaptic Development, Neurotrophic Signalling

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CityU

Glial Biology, Neurodevelopment

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CityU

Neuronal-Glial Fate Determination and Interaction

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HKUST

Axon Regeneration, CNS Injury Recovery

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CityU

Axon Regeneration

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HKU

Neurogenomics, Adaptation, Environmental Effect on Behaviour

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EduU

Neural Stem Cell, Neurodegenerative Diseases

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HKU

Cell Biology of Neurogenesis

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CityU

Genomics, Networks Mapping, Neurodevelopment

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